Sephin 1

Research use only, not for human use.

Sephin1 is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.

Sephin1 is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.

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Animal Model:C57BL/6J female mice immunized with MOG35-55/CFA to induce chronic EAE Dosage:4 mg/kg, 8 mg/kg Administration:I.p.; daily for 35 days Result:Significantly delayed clinical disease onset with both dosages, but to a greater extent with the 8 mg/kg treatment.Animal Model:Five-week-old female FVB mice (intracerebrally with mouse-adapted RML prions)Dosage:100 μg Administration:I.p.; 3 times per week for 60 days, after 60 days of treatment, the treatment was reduced to two i.p. injections per week for another 20 days.Result:Significantly prolonged survival of prion-infected mice.

lcerguastat | IFB-088

Metabolic Enzyme/Protease

Phospholipase

phosphatase?PPP1R15A (R15A)

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951441-04-6

196.64

C8H9ClN4

>98% (HPLC)

DMSO:200mg/ml(1017.10mM; need ultrasonic)

NC(N)=N/N=C/c(cccc1)c1Cl

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(-20℃)

With Ice Pack

≥ 2 years